I personally don't use presets that much, but in general I think they're a tool just like anything else. Either as a starting point for tweaking or just as they are. Sometimes people say it's cheating, boring, "makes you sound like everybody else" etc, but... I think there's just so much more to making music than sound design, and for some that's an important part and for some it's not.
That said, some specific presets may be so widely used that they can't be used without getting associated with other things. Just like a specific sample that's already been used in other things may not be a good idea to use again.
Either way, I think the only people that care at all are other producers, who probably aren't your key demographic for your music.
