I actually demo'd Nexus at a buddy's house, and I honestly didn't like a number of the sounds from my own standpoint and what I usually like to create. The factor of it also being just a sampler with some sounds was overall a turn-off, but I have to admit, a number of the pianos were incredibly well, hell, even the cheesy ones, The orchestral sounds like Brien mentioned were also top notch.
I wouldn't blame anyone for using Nexus, but personally me, just seems like a turn off when I can have full control in synthesizers.