(I'm assuming you're talking about vocals in Serum.)
With a little bit of work, you can get short monophonic vocals into Serum's wavetable synthesizer. If you scan through the wavetable at a constant speed while playing a note, it will actually reproduce the the vocal sample. So by applying an envelope, LFO, or manual automation to the wavetable position you can get a lot of different articulations off the same vocal.
From there, you can apply warp modes like Bend +/- or Asymmetry, or some FM from oscillator B (try a sine wave an octave above or an octave below!), and either change the tonality of the vocal or start modulating those and turn your vocal into a gnarly bass growl.
Also for an easy Melbourne Bounce lead, take a long vowel sound from a vocal, consolidate it to a new sample, load it into Serum, make it monophonic and apply a lot of glide and distortion.