I did once try to re-create guitar sound on Zebra and eventough it has this cool comb filter that is awesome for that, you just can't accomplish the level of realism. (Or at least I wasn't. Came far, it was a guitar, but a bit odd.) It always falls down to uncanny valley area. Pianoteq and Applied Acoustics Systems went closest to emulating real things as far as I know. ...and even there it's not as perfect as reality. ...so I usually choose to use multisamples or make real recordings of real instruments and try to make something brand new and nice on the synthesiser.

continuing my rant i just kinda wanted to ask--do you guys feel that super high sampling/bit rates really improve the sound quality? i usually work at 44.1K or 44.8K out of habit but I'm wondering whether you notice a difference and (more importantly) whether or not fans/listeners would care?
Nope. We don't hear anything above 20kHz (well, 17-18 in most cases :p), which gives the audio two points per sinewave at 44.1kHz. More than enough considering it's inaudible up there. I do work at 96 though, as I don't have to force plugins to oversample that much to perform anti-aliasing. But as a distribution format, 44.1 is absolutely fine.