I've had some readability troubles with the standard template (in another topic here, the small quote text is mentioned already), so at first I chose another, but that didn't have all the features of the standard template, so I did some custom CSS styling using a browser extension (I use 'Stylish':
https://chrome.google.com/webstore/detail/stylish/fjnbnpbmkenffdnngjfgmeleoegfcffe?hl=en).
Here's the code I'm currently using and what it does:
body { font-size: 88% !important; font-family: Verdana !important } // the custom font is quite beautiful, but I found it hard to read, so I replaced it with Verdana
#mainframe { font-size: 100% !important } // I'm also making it a bit larger
.poster h4 { margin-left: 0.75em !important; height: 100% !important; width: auto !important } // this left-aligns the user names with the rest of the poster's info when using Verdana.
blockquote { font-size: 100% !important; padding: 15px !important } // makes the quotes larger
.keyinfo h5 { font-size: 65% !important } // these two lines adjust the size of the auxiliary info around the post, which is currently quite prominent when compared to the post contents
.smalltext { font-size: 0.65em !important } // it also reduces visual clutter
.windowbg { background-color: #e7eaef !important } // this enables alternating colors for posts. makes it easier to tell them apart
.windowbg2 { background-color: #f7faff !important }.poster { margin-bottom: 1em !important } // these three lines move the "edited by" info and the links to report posts to the bottom of the post. reduces visual clutter
.postarea { margin-bottom: 1em !important; height: 100% !important }.moderatorbar { clear: both !important; overflow: hidden !important }The overall effect is much better readability, more focus on the post content as opposed to user interface, and reduced visual clutter. The downside is that the new font is a lot less pretty. I'll take it though!

Here are two before-after comparisons:
BeforeAfterBeforeAfterI hope this helps someone! And perhaps a few of the changes may be something for the board operators to think about.