Like Ocular said, doing quarter tones is overly difficult because of the piano setup, and as most said, you would have to create two synths. I did personally find an optimal way by linking the detune to a controller ( I personally set it to a button that is on my midi keyboard.) and set min at the normal chromatic scale and the max to the 0.5 as to reach all 24ish notes so every time I interchanged with notes in between chromatic notes, I pressed the button so as soon as I hit the key at the same time the note is a quarter tone above that. I've never actually made a song like this though, because like they said, even then, it is still pretty difficult and a lot of work just to get it to work.